wingo777

OSAKA, Japan and MONTREAL , Dec. 5, 2024 /PRNewswire/ -- Ono Pharmaceutical Co., Ltd. (Headquarters: Osaka, Japan ; President: Toichi Takino; "Ono") announced that it has entered into a drug discovery collaboration agreement with Congruence Therapeutics (Headquarters: Montreal, Quebec, Canada ; CEO: Clarissa Desjardins; "Congruence") to generate novel small molecule correctors against multiple protein targets in the oncology area by leveraging Congruence's proprietary drug discovery platform, RevenirTM. Under the terms of the agreement, Congruence will generate small molecule correctors by leveraging Congruence's proprietary drug discovery engine called, RevenirTM. Ono will obtain an exclusive option right to develop, manufacture and commercialize the identified small molecule correctors worldwide. Congruence will be eligible to receive an upfront payment, research expenses, milestone payments based on research and development progress and sales, as well as tiered royalties based on net sales. "We believe that this collaboration with Congruence may help generating novel small molecule correctors for validated targets in the oncology area by leveraging their own technologies in protein dynamics and computational biology, leading to our development pipeline," said Seishi Katsumata , Corporate Officer / Executive Director, Discovery & Research of Ono. "We will be committed to delivering innovative new drugs to cancer patients as soon as possible." "Congruence is thrilled to partner with Ono, which has established itself as a global leader in drug development, particularly in the oncology space. We believe that our RevenirTM platform and capabilities in protein dynamics will accelerate the discovery of novel therapies for compelling targets of interest to both companies," said Sharath Hegde PhD, Chief Scientific Officer of Congruence. About RevenirTM Drug Discovery Platform RevenirTM, Congruence's proprietary computational drug discovery platform, captures the dynamic biophysical changes caused by mutations in proteins, offering unique insights into protein defects and their correction. By examining surface features and a spectrum of biophysical descriptors across an ensemble of protein conformers, RevenirTM predicts small molecule induced correction of the underlying defect. About Congruence Therapeutics Congruence is a computationally-driven biotechnology company building a unique pipeline of transformative small molecule correctors rationally designed to rescue aberrant protein function. Congruence's proprietary scalable platform, RevenirTM, captures the biophysical features of proteins across their conformational ensembles, in order to identify novel allosteric and cryptic pockets which are virtually screened to generate novel chemical matter. For more information, please visit www.congruencetx.com . View original content to download multimedia: https://www.prnewswire.com/news-releases/ono-enters-into-drug-discovery-collaboration-agreement-with-congruence-therapeutics-to-generate-novel-small-molecule-correctors-in-the-oncology-area-302324452.html SOURCE Ono Pharmaceutical co., ltd.

ESTERO, Fla. (AP) — Sydney Shaw scored 20 points and made four 3-pointers, JJ Quinerly added 14 points and No. 12 West Virginia handed Boise State its first loss, 82-47 on Saturday in the Gulf Coast Showcase. West Virginia advances to the championship game on Sunday, while Boise State plays for third place. The Mountaineers have started 8-0 in back-to-back seasons after last year's 11-0 beginning. Quinerly also had three steals to help West Virginia reach double figures in that category in every game this season. The Mountaineers also forced 20-plus turnovers for the eighth straight game. Boise State was held to just six points in the first and third quarters. West Virginia went on two 10-0 runs in the first quarter to build a 16-point lead. The Mountaineers led by double figures the rest of the way. It was 45-23 at halftime then Quinerly scored four straight points to begin a 9-0 run that ended in a 32-point lead. Freshman Jordan Thomas, coming off her first career double-double, had 10 points and six rebounds for West Virginia. Elodie Lalotte scored 11 points for Boise State (7-1). Teryn Gardner addd 10. West Virginia was coming off an 89-54 victory over High Point on Friday to begin the tournament. The Mountaineers led by as many as 39 points and forced 22 turnovers in that one. ___ Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP women’s college basketball: https://apnews.com/hub/ap-top-25-womens-college-basketball-poll and https://apnews.com/hub/womens-college-basketballA TikTok sale under Trump? Experts say it could actually happen this timeVanna White Asked Fans To Write In And Come Up With A Nickname For Wheel of Fortune’s Ryan Seacrest. The Answers Were Wild

BOONE, N.C. (AP) — Myles Tate led Appalachian State with 20 points and Dior Conners hit the game-winning 3-pointer with one second left as the Mountaineers defeated William & Mary 79-76 on Sunday. Tate had five rebounds and 10 assists for the Mountaineers (3-2). Conners went 5 of 9 from the field (5 for 8 from 3-point range) to add 15 points. CJ Huntley shot 6 of 9 from the field and 1 for 4 from the line to finish with 14 points. Noah Collier led the Tribe (3-5) in scoring, finishing with 19 points and eight rebounds. William & Mary also got 13 points from Malachi Ndur. Kyle Pulliam also had 12 points. Appalachian State went into the half leading William & Mary 42-30. Jamil Muttilib put up 12 points in the half. Tate led Appalachian State with 15 points in the second half. NEXT UP Appalachian State plays Wednesday against Sam Houston, and William & Mary visits Old Dominion on Monday. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .

Australian PM ready to 'engage' with Musk on social media teen ban